The Infected are very common in Terra, owing to the fact that Originium, the prime cause of Oripathy, plays an important role in the Terran industry and technology.
Because of the Terrans' deeply rooted hatred towards the Infected ever since the ancient times, Infected in many Terran countries are shunned and discriminated by the non-Infected. Such hatred stems from the fact that Oripathy is (as of the current timeline) incurable and could spread via direct contact (though this is a popular, exaggerated misconception) or upon the disintegration of the Infected's body and crystallization into Originium Dust on death.
The treatment of the Infected varies by the country, with the following being the worst:
- Ursus is infamous for rounding up and killing the Infected in various pogroms carried by the Ursus Imperial Army in a similar way to the various anti-communist massacres in our world (most notably, the ones in China and Indonesia) or the Soviet Great Purge. A Reunion member recalled this experience, where he managed to survive by hiding in the other Infected's corpses.
- Chernobog was one of the many areas in Ursus that saw the worst treatment against the Infected, with people even cheering amidst anti-Infected pogroms around the city.
- It is implied that Yen treats the Infected in a similar way to Ursus, though to a much lesser degree. This can be seen the fact that the Yen emissaries visiting Lungmen, particularly their leader Leizi, holds a prejudiced view towards the Infected. Their presence is also why Wei Yenwu ordered the Infected in Lungmen's slums to be purged.
- The Infected in Victoria are confined into quarantine zones, regardless of age and gender, with non-Infected who hide the Infected facing severe punishments.
- In Kazimierz, Infected knights participating in the Kazimierz Major are segregated through an institution known as "Infected Participation System," where they are forced to take part in a bloodsport against gloompincers and sometimes each other.
Most Terran countries, however, treats the Infected better (if not as bad) than the above:
- Columbia is known for their lack of discrimination towards the Infected, even they are treated equally as the non-Infected. However, Infected migrants have to earn the Columbian citizenship through service as workers, which means that the Infected are seen as cheap labor in Columbia. It could arguably be seen, however, in a way, as a mutually beneficial system for both sides.
- Any Lateranian who becomes Infected for various reasons will be banished from the country while retaining the Lateranian citizenship and rights. Infected Lateranians can even return to their homeland under certain extraordinary circumstances.
- Even though Leithania has laws which mandates that Infected whose Oripathy reaches a certain stage has to be euthanized, the Infected are otherwise simply kept into quarantine zones.
- The Infected in Minos are seemingly not discriminated/segregated, as they can participate in the Hymnoi Wisdom. The only exception to this is for the Minoan Twelve Hero cult, where the position within its clergy is only open to non-Infected. If a priest(ess) of the hero cult were to be confirmed to be Infected, they will face demotion.
- While Rim Billiton does not persecute the Infected, they are often billed by high medical treatment costs and often refused when looking for employment.
- While most Sargonian lords neglect the Infected and let them die a slow, painful death, not all of them do. Some, notably the Tulla family, will quarantine the Infected in specifically designated "Infected quarters" and provide them with medical treatment.
- The tribes in the jungles of eastern Sargon, however, have no knowledge about Oripathy whatsoever, which they simply see it as a "stone disease." As the result, discrimination/persecution against the Infected in the jungle tribes is literally non-existent.
It is, however, an important thematic of Arknights' storytelling that the countries that do not outright persecute the Infected are more than likely "whitewashing" their prejudice and concealing some other form of exploitation of the Infected. The harsh treatment faced by the Infected is the main contributor to the bleakness of Arknights' setting, although it is also very frequently pointed out that strife and oppression does not stop at the Infected, and the specter of Oripathy is only one of Terra's many problems.
The majority of Infected who suffered from the Terrans' prejudice have become distrustful and embittered towards the non-Infected, with some even harboring deep feelings of vindication, that led to them using violent methods to liberate the Infected from misery, as attested by the existence of the Reunion Movement. Some Infected, however, choose to seek for non-violent methods to end their suffering, with Rhodes Island being the most notable of them.